Encyclopedia Of Biological, Physiological and Health Sciences - Table of Contents

SPORT SCIENCE AND PHYSICAL EDUCATION

SPORT SCIENCE, HEALTH AND PHYSICAL EDUCATION

Relevant Historical Dates On Sport Science, Physical Education And Health

Health through Movement – A Holistic Approach

Present Knowledge of Health and Human Movement

Interdisciplinary Approaches In Sport Science And Physical Education

Sport Science, Physical Education and Globalization

KINESIOLOGY - HUMAN MOVEMENT SCIENCE

Movement in Human Life

Movement and Accompanying Emotions

Development of the Science of Kinesiology and Its Creators (Figure 1-6)

Movement in Textbooks of Kinesiology

Kinesiology - Science with Many Names

Kinesiology - Rebirth in the Best Time?

Anthropokinesiology in Universities’ Curricula

Recapitulation – Summary

SPORT AND EXERCISE PHYSIOLOGY: PERFORMANCE-ENHANCING SUBSTANCES - ANABOLIC STEROIDS

Introduction

Anabolic Steroids: Historical Perspective

How Anabolic Steroids Work

Anabolic Steroids and Performance

Health Effects of Anabolic Steroid

Importance of Dosage

Anabolic Steroids and the Law

COMPARATIVE PHYSICAL EDUCATION AND SPORT

Introduction

Comparative Education

Comparative Physical Education and Sport

Methodology

The International Society for Comparative Physical Education and Sport - ISCPES

Tendencies in Publications

Comparative Study in the Global World and International Development

The Future in Comparative Physical Education and Sport

PHYSICAL EDUCATION IN HIGHER EDUCATION

Introduction

Physical Education and Sports

A Historical Approach towards Physical Education

Physical Education Curricula and PE in Schools

Teaching and Physical Education Teaching

Estimates Concerning the Future

Conclusion

ADAPTED PHYSICAL ACTIVITY AND INCLUSIVE PHYSICAL EDUCATION

Introduction

People First Terminology = Sensitive Terminology

The Concept of Adapted Physical Activity

The Body of Knowledge of APA

The Concepts of Inclusion

Inclusion in Physical Education

Models of Good Practice

Conclusion and Perspectives

HEALTH AND FITNESS

Introduction

Extrinsic Factors Influencing Health and Fitness

Intrinsic Factors Influencing Health and Fitness

Conclusions and Perspectives 

LEISURE AND TOURISM

General Introduction

Historical Overview of Leisure and Tourism around the World

Educational Perspective

Career Opportunities

Challenges and Trends for the 21st Century in Leisure and Tourism

Conclusions and Perspectives

EXERCISE AND AGING

General Introduction

Effects of Aging and Exercise on Aerobic Fitness

Effects of Aging and Exercise on Cardiovascular Function

Effects of Aging and Exercise on Skeletal Muscle Mass and Function

Genetic background of aging-related phenotypes

Conclusion

NEW REALMS OF AGENCY: PROMOTING PEACE EDUCATION AND GENDER EQUITY THROUGH SPORT

Introduction

New Realms of Agency: The Impact of Sport Interventions

Integrating a Gender Perspective

Racism and Xenophobia

Bridges to Understanding: Sport Activists

Sport’s Role Acknowledged by Non-Sport Affiliated Contemporary Agencies: Non-Governmental Organizations and Social Movements

Concluding Remarks – Recommendations: An All-Encompassing Hub of Information for Peace

SPORT AND EXERCISE PSYCHOLOGY

Doing Sports and Exercise: Meanings and Feelings

Sport and Exercise as a Complex Social and Psychological Phenomenon

Conceptual Framework in Sport and Exercise Psychology

Competition, Intensity, and Motivation

Mental Techniques for the Improvement of Performance

Starting, Adopting, and Maintaining Exercise Habits: Theoretical Approaches and Motivational Factors

Sport and Exercise as Means for Community Building and Community Organization

SPORT MANAGEMENT

Introduction

Strategic Management

Diversity Management

Ethical Decision Making

Sport Economics

Sport Business and Finance

Facilities and Event Management

Human Resource Management

Corporate Social Responsibility and Sport

Sport and Development

Sport Law

Sport Governance

Management of Sport in a Global Society

SOCIOLOGY AND PHILOSOPHY OF SPORT

Sociology of Sport

Philosophy of sport

SPARTIAN GAMES - THE GAME MODEL OF INTEGRATION OF SPORT AND ART

What is SpArtian Games?

Special Features and Value Of Spartian Games

THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES

FLAXSEED IN CARDIOVASCULAR HEALTH AND DISEASE

Flaxseed and Its Components

Pharmacological Activity of Flaxseed and Its Components

Mechanism of Atherosclerosis

Flaxseed and Its Components on the Mechanisms of Atherosclerosis Development

Flaxseed and Its Components on Risk Factors for Atherosclerosis

Flaxseed Components and Atherosclerosis

Health Benefit

Side Effects of Flaxseed and Its Components

CAROTID ENDARTERECTOMY

Historical Background Leading to Current Randomized Studies

Randomized Clinical Trials examining Carotid Endarterectomy

Carotid Endarterectomy – Surgical Technique

Trials comparing Carotid Artery Stenting with Carotid Endarterectomy

ABDOMINAL AORTIC ANEURYSMS

Historical Background

Abdominal Aortic Aneurysms

Anatomy

Pathophysiology

Etiology

Diagnosis

Surgical Treatment

Indications for Repair

Open Repair

Endovascular Repair of Abdominal Aortic Aneurysm

Open Arterial Access Technique

Endovascular Repair of Proximal Abdominal Aortic Aneurysm

Iliac Conduit for EVAR for Severe Occlusive Disease at the External Iliac Arteries

Fenestrated Stents

Branched Stents

Non-Resective Repair of AAA (Hacker et al 2011)

Recent Studies

Short Term Results of EVAR

DREAM Trial (Prinssen et al 2004)

DREAM Follow-Up (Blakensteijn et al 2005)

Dream Update (De Bruin et al 2010)

EVAR 1 Trial (Greenhalgh et al 2004)

EVAR 1 Trial Follow-Up (Greenhalgh et al 2005)

EVAR 1 Long-Term Results (Greenhalgh et al 2010)

EVAR 2 Trial (EVAR trial participants. 2007)

Eurostar Registry (Harris et al 2000; Laheij et al 2000)

Current FDA-Approved Endografts for AAA:

Personal Data

Endovascular Repair of an Iliac Artery Aneurysm

Endovascular Procedures in Azotemic Condition Using CO2.

MANAGEMENT OF CHRONIC ISCHEMIA OF THE LOWER LIMBS

Incidence

Disease Progression

Risk Factors and Management

Pharmacotherapy

History and Physical

Diagnostics

Treatment

CAROTID ARTERY STENT AND MEDICAL MANAGEMENT OF CAROTID DISEASE

Carotid Disease

Carotid Artery Stenting

Medical Management of Carotid Disease

Guideline Approaches

MANAGEMENT OF SUBCLAVIAN VEIN THROMBOSIS KNOWN AS PAGET-SCHROETTER SYNDROME

Definition

Anatomy of the Obstructing Site

Diagnosis

Immediate Therapy

Thrombolysis

Surgical Treatment

The Operation

Post-Operative Assessment

Post-Operative Care

Suboptimal, Ineffective, or Wrong Treatments

Other Surgical Procedures

CURRENT MANAGEMENT OF MAJOR UPPER AND LOWER EXTREMITY VASCULAR TRAUMA

General Management of Upper and Lower Extremity Arterial Injuries

Surgical Management of Arterial Injuries

Medical Management of Arterial Injuries

Diagnostic Imaging

Associated Orthopedic Injuries

Venous Injury Repair

Fasciotomy

Upper Extremity Nerve Injuries

Soft-Tissue Deficits

Amputation

Forearm Arterial Injuries

Proximal Upper Extremity Arterial Injuries

Femoral Arterial Injuries

Popliteal Arterial Injuries

Below-Knee Arterial Injuries

Endovascular Treatment

Discussion

VASCULAR EMBOLIZATION: INDICATIONS, MATERIALS AND TECHNIQUES

Permanent Larger Embolic Agents

Permanent Smaller Embolic Agents

Liguid Embolic Agents

Temporary Embolic Agents

Technique and Equipment

ENDOVASCULAR REPAIR OF THE THORACIC AORTA

Evolution of Endovascular Technology

Aortic Pathology Treated with Endovascular Grafting

Operative Strategies for Endovascular Grafting

Complications of Endovascular Grafting

Overall Outcomes

MANAGEMENT OF VALVULAR HEART DISEASE - SURGICAL PERSPECTIVE

Pathophysiology of Regurgitant and Stenotic Lesions

Aortic Valve

Mitral Valve

Tricuspid Valve

Pulmonary Valve

Infective Endocarditis

MEDICAL SCIENCES

MEDICAL INFORMATICS AND TELEMATICS AT THE THRESHOLD OF THE 21ST CENTURY

Introduction

Brief History

Institution-centered Informatics

Patient-centered Informatics

Community-centred Informatics

Standards in Medical Informatics

Data Security, Confidentiality and Privacy in Medical Informatics

Medical and Health Informatics Education

Promoting Medical Informatics

THE PAST AND FUTURE IMPACTS OF HEALTH/MEDICAL INFORMATICS ON HEALTHCARE DELIVERY

Introduction

The Use of Computers in Health Care Is Reducing Errors and Improving Patient Safety

The Benefits of a Unified Electronic Health Record

Computer Technology in Primary Care and Chronic Disease Management

Using Communications Technology to Traverse Space at the Speed of Care

Conclusion

HUMAN ASPECTS OF HEALTH CARE INFORMATION SYSTEMS

Introduction

Background

Towards a Framework for Considering HCI in Health Care

Human-Computer Interaction and the System Development Life Cycle

Usability Engineering Methods for the Iterative Evaluation and Improvement of Health Information Systems

Examples of Emerging Technologies in Health Care User-Computer Interfaces

Conclusion - Need for Cognitive Approaches to System Design in Health Care

CLINICAL INFORMATICS

Introduction

Background: The Origins of Clinical Informatics

The Emergence of Healthcare Information Technology and the Electronic Health Record (EHR)

Issues with Electronic Health Record Systems

Emergence of Clinical Decision Support Systems (CDSSs) and On-line Clinical Guidelines

Monitoring Systems

Clinical Departmental Systems

Hospital-Wide Clinical Information Systems

Discussion

Conclusion

PATHOGENICITY, VIRULENCE AND EMERGING PATHOGENIC STRAINS OF ESCHERICHIA COLI TRANSMITTED THROUGH FOOD AND WATER WOOD PHYSICS AND DRYING

Introduction

Taxonomy

Reservoir

Pathogenic E. coli

Concluding Remarks

FOOD SAFETY – ITS ROLE IN HEALTH AND DEVELOPMENT: THE PROBLEMS RELATED TO OUR FOOD SUPPLY

The problems related to our food supply

CONSUMER PERCEPTIONS OF FOOD SAFETY

Introduction

Consumer Perceptions of Risk

Risk and Benefit

Trust in Food and Actors in the Food Chain

Individual Differences

Conclusion

THE NEED FOR AN INTERNATIONAL APPROACH – THE ROLE OF FAO AND WHO

Introduction

Food Safety Risk Assessment at the International Level

Food Safety Risk Management at the International Level

HOME FOOD SAFETY AND CONSUMER RESPONSIBILITY

Introduction

Incidence and cost of foodborne disease

Foodborne disease incidence associated with the home

Bacterial contamination and the domestic kitchen

The role of the consumer

Consumer food preparation and consumption patterns

Mechanisms for assessing consumer food safety behavior

Consumer knowledge of food safety issues

Consumer attitudes to food safety in the home

Consumer food preparation behavior

Consumer food safety education

Conclusions

MANAGEMENT OF FOOD SAFETY IN THE INDUSTRIAL SETTING

Introduction

Risks and Controls along the Food Supply Chain

Role of Food Technologies in Ensuring Food Safety

Safety and Quality Assurance System

Challenges and Outlook

Conclusions

FOOD SAFETY AT THE NATIONAL LEVEL - THE ROLE OF GOVERNMENTS

Introduction

Threats to Food Safety

Food Safety – A Shared Responsibility

A Role for Government

Integrated Controls from Farm-to-Fork

Responsibilities for Food Control at Government Level

Food Laws and Regulations

Management of Official Food Controls

Inspection Services

Laboratories, Monitoring and Surveillance

Information, Education and Communication

Conclusion

PALEOCLIMATOLOGY AND PALEOECOLOGY

Prelude: Aim and Scope of the Chapter

Concepts and History

Precambrian: Changing Climates of Early Ecosystems

Paleozoic (542-251 Ma)

Mesozoic (252-65 Ma)

Cenozoic

Concluding Remarks

SYSTEMATIC PALEONTOLOGY

Systematics and Biodiversity

Evolution and Classification

Competing Systematic Philosophies

Cladistics and Classification

Molecular Systematics

Phylogenetic Methods and Software

Codes of Taxonomic Nomenclature

Conclusions

EVOLUTIONARY DEVELOPMENTAL BIOLOGY: ANCIENT ROOTS AND NEW PERSPECTIVES

Introduction

Fundamental questions in EvoDevo

History of EvoDevo

The Morphological Regularities Of Evolution – A.N. Sewertzoff

The Factors Of Evolution – Ivan I. Schmalhausen

Convergent Evolution Of Ideas – Schmalhausen And Waddington

Embryos, Ancestors And Heterochrony - Sir Gavin. R. Debeer

The Homeobox And The Rebirth Of Evodevo

Important Contepts In Contemporary Evodevo

BACTERIA AND ARCHAEA

Prokaryotes: the unseen majority

The Species Concept for the Prokaryotes

Bacteria And Archaea, The Two Domains of the Prokaryotic World

The Differences Between Bacteria And Archaea

The Prokaryotes A Taxonomic Overview

Prokaryotes: The Uncultured Majority

EMBRYOPHYTA

Short Introduction to Green Plants

Embryophytes - Characteristics and diversity

Bryophytes

Tracheophytes (vascular plants)

Progymnosperm concept: the "emblematic" fossil plant Archaeopteris.

Seed plants

Introduction to the Angiosperms

KINGDOM FUNGI

Introduction

Fungal Biology

Fungal ecology

Fungal taxonomy and systematics

Fungal genomics

Introduction to major fungal groups

Future outlook

AMBULACRARIA

General Introduction

The Echinodermata

Hemichordata

Plactosphaeroidea (Xenoturbella)

CHORDATA

Characteristics and Diversity of Chordates

Origin of Craniates and Jawless Vertebrates

Evolution of Gnathostomes

Actinopterygians

Sarcopterygians

Limbed Vertebrates

Amniotes

SPIRALIA/LOPHOTROCHOZOA

Introduction to Spiralia and Lophotrochozoa

Phylogeny of Spiralia

Gnathifera

Rouphozoa

Lophophorata

Nemertea

Entoprocta & Cycliophora

Mollusca

Annelida

The problematic positions of Dicyemida, Orthonectida & Chaetognatha

Cultural impact and relevance to human welfare

ECDYSOZOA

Introduction to Ecdysozoa

History

Internal Phylogeny of Ecdysozoa

Characteristics and Diversity of Ecdysozoans: Arthropoda

Characteristics and Diversity of Ecdysozoans: Cycloneuralia

ORIGIN AND EVOLUTION OF HEXAPODA

Introduction

The Hexapoda: An Ancient Story

The Major Insect Clades

The Hexapoda and the Great Environmental Changes

BASAL METAZOANS

Introduction on "Basal Metazoans"

The Phylogenetic Relationships among Non-Bilaterian Metazoa

Phylum Porifera

Placozoa

Ctenophora (comb-jellies)

Phylum Cnidaria

Cultural Impact, Relevance to Human Welfare, And Sustainable Development

THE PROTIST

Introduction

A very brief history

Diversity, classification and nomenclature

Archaeplastida

Cryptista

Haptista

Stramenopiles

Alveolata

Rhizaria

Amorphea and Obazoa

Amoebozoa

Discoba

Metamonada

MEDICINAL AND AROMATIC PLANTS OF THE WORLD

PHYTOCHEMISTRY OF SAPINDUS MUKOROSSI AND MEDICINAL PROPERTIES

Introduction

History

Traditional Uses

Phytochemistry

Medicinal Properties

Conclusion

IMPORTANT MEDICINAL PLANTS OF ETHIOPIA: USES, KNOWLEDGE TRANSFER AND CONSERVATION PRACTICES

Introduction

Methods of Screening Criteria of Important Medicinal Plants

Important medicinal plants from Ethiopia and their uses

PHYTOCHEMISTRY OF CHIA SEEDS (SALVIA HISPANICA), BERRIES AND MEDICINAL PROPERTIES

Introduction

Salvia hispanica (Chia Seeds)

Berries

BIOCHEMISTRY AND PHYTOCHEMISTRY OF TRIPHALA, THREE MEDICINAL FRUITS, MEDICINAL PROPERTIES, BIOACTIVE COMPOUNDS AND THERAPEUTIC POTENTIAL

Introduction

Bioactive phytochemicals of Triphala

Therapeutic application

Pharmacological properties of Triphala

Safety studies on Triphala

Conclusions and recommendations

PHYTOCHEMISTRY, MEDICINAL PROPERTIES, BIOACTIVE COMPOUNDS AND THERAPEUTIC POTENTIAL OF THE GENUS COMBRETUM (COMBRETACEAE)

Introduction

Ethnopharmacology

Phytochemistry and antioxidant content

Therapeutic effects

Conclusions

FENUGREEK NUTRACEUTICAL PROPERTIES AND UTILIZATION IN VARIOUS FOOD PRODUCTS

Introduction

Use of Fenugreek as Nutraceutical

Fenugreek in foods

Conclusions and Perspectives

IMMUNOLOGY AND IMMUNOPATHOLOGY

EVOLUTION

Introduction: The Nature of Evolution

Major Transitions in Evolution

Different Approaches to the Study of Evolution

Microevolution

Adaptive Evolution

Neutral Evolution

Species and Speciation

Macroevolution

Phylogeny

Evolution, Complexity, and the Information Content of Living Beings

HISTORY OF EVOLUTIONARY THEORY

Scientific Historiography and the Analysis of the Theoretical Concepts

The Definition of "Species"

The Problem of Classification

Linneus, the "System" and the "Methods"

Buffon and the nuance of Nature

The Historical Dimension and the Re-orientation of Natural History

Lamarck and Transformism

Paleontology and Geology

THE DARWINIAN VIEW OF LIFE

Evolutionism and Darwinism

What are the Laws of Life?

The Structure of a New Theoretical Picture

The Origin of Species and its Critics

Toward a Natural History of Mind

EVOLUTION AND THE SPECIES CONCEPT

Historical Aspects

Current Paradigms and Challenges

A Case Study

The Future: Towards a Holistic Approach?

SPECIATION AND INTRA-SPECIFIC TAXA

Time frame for speciation

Ecological considerations

Genetic models of speciation

Modes of speciation

Speciation in plants

NATURAL SELECTION AND THE EFFECTS OF ECOLOGICAL INTERACTION ON POPULATIONS

Natural Selection

Non-selective Aspects of Population Biology

Deterministic and Stochastic Concerns in Population Biology

CELL AND TISSUE STRUCTURE IN ANIMALS AND PLANTS

Cell and tissue development

Cell Ultrastructure

Selected Examples of Differentiated Cell Types

General Organisation of Tissues

Some Examples of Specialised Tissue Types

BIOLOGICAL HOMEOSTASIS

Stabilization

Homeostasis

Homeorrhesis, the Control of Behavior

Control of Development and Reproduction

PATTERNS AND RATES OF SPECIES EVOLUTION

Biological and morphological species concepts

Evidence from ecology and palaeobiology

Fossil evidence of speciation.

Species diversification through time

Evolutionary patterns and processes

CLASSIFICATION AND DIVERSITY OF LIFE FORMS

Natural vs. artificial classifications

Classification vs. system

Nomenclature

The diversity of life

Taxonomy and nomenclature of domesticated animals and cultivated plants

The tools of classification

HISTORICAL REVIEW OF SYSTEMATIC BIOLOGY AND NOMENCLATURE

The Origins

From Classical Antiquity to the Renaissance Encyclopaedias

From the First Monographers to Linnaeus

Concepts and Definitions: Species, Homology, Analogy

The Impact of Evolutionary Theory

The Last Few Decades

Nomenclature

Natural History Collections

METABOLIC DIVERSITY IN PROKARYOTES AND EUKARYOTES

The Thermodynamic and Mechanistic Basis of Cellular Metabolism

Metabolic Diversity Within the Three Domains of Life: Archaea, Bacteria and Eucarya

Phototrophy - The Use of Light as Energy Source

Heterotrophy

Chemoautotrophy

Metabolic Diversity and the Cycles of Carbon, Nitrogen, Sulfur and Other Elements

Introduction

DIVERSITY OF FORM, FUNCTION AND ADAPTATION IN MICROORGANISMS

Cell Size and Cell Shape in the Procaryotes

The Outer Layers of the Procaryotic Cell

Special Intracellular Structures

Motility Organelles

Survival and Dispersal Forms

Multicellular Differentiation and Special Life Cycles in Procaryotes

Diversity of Form, Function, and Adaptation - The Lower Eucaryotes and the Procaryotes Compared

Introduction

DIVERSITY OF FORM, FUNCTION AND ADAPTATION IN FUNGI

Diversity of Form

Reproduction

Diversity of Function

Adaptation

Economic Relevance of Fungi

EVOLUTIONARY AND MOLECULAR TAXONOMY

Basic Concepts

Molecular Methods used in Systematics

Phylogenetic Analysis

Future Developments

SYSTEMATIC ZOOLOGY: INVERTEBRATES

Introduction to the systematic zoology of the Metazoa (Animalia)

Animal phylogeny: data sources and interpretation

Systematic zoology of the Metazoa

Alternative hypotheses of metazoan relationships

Reconciliation and pathways to future progress

PORIFERA, CNIDARIA, AND CTENOPHORA

Porifera

Cnidaria

Ctenophora

PLATYHELMINTHES, NEMERTEA, AND "ASCHELMINTHES"

General Morphology

Platyhelminthes, the Flatworms

Nemertea (Nemertini), the Ribbon Worms

“Aschelminthes”

ANNELIDA

Basic annelid organization

Annelid anatomy

Annelid diversity

Annelid behavior and physiology

Reproduction and development

Annelid phylogeny

ARTHROPODS OTHER THAN INSECTS

Myriapoda

Crustacea

Cheliceriformes [= Cheliceromorpha]

INSECTS AND OTHER HEXAPODOUS ARTHROPODS

What are Insects?

Why are Insects so Successful?

Insect Life Cycles

Ecological Importance of Insects

Insect Diversity

MOLLUSCA

Relationships and Higher Classification

General Morphology of the Mollusca

Gastropoda

Bivalvia (=Pelecypoda)

Cephalopoda

Other Classes - Living and Extinct

Current Knowledge

Geographic Diversity

Ecological Diversity

Conservation

Economic Importance

ECHINODERMATA

General Morphology of the Echinodermata

Classification and Relationships of the Echinodermata

Edrioasteroid-like Echinoderms

Blastozoans

Crinoidea

Asteroidea

Ophiuroidea

Holothuroidea

Echinoidea

Ongoing and Future Research

OTHER INVERTEBRATE TAXA

Mesozoa

Xenoturbellida (Xenoturbella Bocki)

Kamptozoa (Entoprocta)

Sipunculida

Tardigrada, the Water-bears

Onychophora, the Velvet Worms

Chaetognatha, the Arrow Worms

Tentaculata, or Lophophorata

Hemichordata

TUNICATA AND CEPHALOCHORDATA

Introduction to Protochordata: General Characteristics

Tunicata

Cephalochordata

REPRODUCTION AND DEVELOPMENT BIOLOGY

THE SCIENCE OF ASSISTED REPRODUCTIVE TECHNOLOGY

Gametes

Embryos

Third-Party Reproduction

Diverse Topics within ART

THE ETHICS OF ASSISTED REPRODUCTIVE TECHNOLOGY

Gametes

Embryos

Third-Party Reproduction

Diverse Topics within ART

PHYSIOLOGY AND MAINTENANCE

Introduction and Background

Models in Studies of Physiology

Cells as Basic Functional Units

Blood Circulation

Respiration

Physical Activity

Food Intake and Digestion

Defense Mechanisms

Excreta and Microflora

Bioterrorism

Old and New Sensory Systems

Nervous Control

Hormonal Control

Reproduction

Cell Deaths and Longevity of the Organism

At Extremes

Principles of Oriental Physiology

Adaptation to Pollution

Homeodynamic Robustness

GENERAL PHYSIOLOGY

Variability

Functional Reserves

Physionome

Functional Task Divisions

Sociophysiology

HOMEODYNAMICS

Feedback and Gain

Intracellular Homeodynamics

Homeodynamics of Cell Numbers

Extracellular Fluid Homeodynamics

Environmental Temperature and Homeodynamics

Environmental Chemical Threats and Homeodynamics

Homeodynamics and Disease

Ecosystem Homeodynamics

G PROTEIN-COUPLED RECEPTORS

Turning the system on

Signaling through several pathways

What do the receptors do?

GPCR families

Receptor regulation

GPCR and human disease

GPCRs as a gold mine for drug development

IONIC CHANNELS OF THE EXCITABLE MEMBRANE

Sodium Channel Protein

Operating of Voltage-Gated Channels

Ligand-Gated Channels

Mechanically Activated Channels

Membrane Receptor-Ionic Channel Coupling

The First -Order Code

MECHANISMS OF CELL VOLUME REGULATION

Factors Determining Cell Volume Under Steady-State Conditions

Physiological and Pathological Causes of Non-Balanced Cell Volume Changes

General Mechanisms of Cell Volume Regulation Under Non-Steady-State Conditions

Physical and Chemical Signals Generated by Cell Volume Alterations: Possible Nature of the Cell Volume Sensor(s)

Transduction of Volume Signal

Contribution of Volume Regulatory Mechanisms to Cell Functions and Pathological States

Perspectives on the Studies of Cell Volume Regulation

THERMOREGULATION

Basic Elements of the Human Thermoregulatory System

Body Heat Balance

Thermoregulatory Reactions to Heat and Cold

Body Heat Loads

Models of the Human Thermoregulatory System

Efficiency of Human Thermoregulation

Gender Differences in Thermoregulation

Acclimation and Acclimatization

Thermoregulation in Children

Other Aspects of Thermoregulation

PAIN AND PROTECTIVE REFLEXES

Physiological and Pathological Pain

Pain Definition

Classification of Pain

Central Pain Pathways

Withdrawal Reflex and Avoidance Behavior Induced by Noxious Stimulation

Regulation of Pain Transmission in the Central Nervous System

Functional and Structural Changes in the Pain Tracts

Responses of Peripheral Nociceptors to Tissue Injury and Inflammation

WOUND HEALING AND REGENERATION

Phased Healing Response

Pathologic Responses to Wounding

Standard and Emerging Therapies for Enhanced Healing

LEARNING AND MEMORY

Learning by Classic Conditioning

Memory

Neural Mechanisms of Memory

Brain Areas Involved in Memory

Amnesia

POSITRON EMISSION TOMOGRAPHY - MOLECULAR IMAGING OF BIOLOGICAL PROCESSES

Introduction: Principles of PET

Radiochemistry

Drug Development, Radiolabeled Drugs, and PET

Brain Receptors and Neurotransmission

Perfusion Imaging

Metabolic Imaging

Clinical Applications of PET

Imaging Gene Expression in vivo using PET

COMPARATIVE PHYSIOLOGY

Introduction: Diversity of Animals

Size, Scaling and Allometry

Physiological Adaptation and Phenotypic Plasticity

Adaptation and Phylogeny

Major Evolutionary Steps in Vertebrate Physiological Adaptation

ENZYMES: THE BIOLOGICAL CATALYSTS OF LIFE

Enzymes as Biological Catalysts

Cofactors

Enzymes in the Cell

Enzyme Turnover

Enzyme Nomenclature

Clinical and Biotechnological Applications of Enzymes

CONCEPT OF ENZYME CATALYSIS

Background

Enzyme Specificity

General Features to Increase the Reaction Rate

Basic Catalytic Mechanisms

Stabilization of the Transition State

Transition State Analogs

Enzymic and Metabolic Equilibria

ON THE DETERMINATION OF ENZYME STRUCTURE, FUNCTION AND MECHANISM

Structure Determination Techniques

Relationship of Enzyme Structure with Enzyme Chemistry and Mechanism

Future Considerations

Introduction

ENZYMES OF DIGESTION

Hydrolysis

Enzymes of Digestion According to Their Sites of Secretion

METABOLISM OF OXYGEN

Oxygen chemistry

Mitochondria and oxygen

Oxygen activation by cytochrome P450

Peroxisomes

Vascular endothelium and xanthine oxidase

Reactive metabolites as bullets of phagocytes

Oxygen damages of biomolecules

Sensing oxygen levels

Oxygen in genome regulation

PROTECTION AGAINST OXIDATIVE STRESS

Introduction and General Considerations

Reactive Oxygen Species and Their Formation

Oxidative Damage and Physiological Significance of Reactive Oxygen Species

Oxidative Stress in Disease

Antioxidant Defence Mechanisms

Antioxidant Supplementation and Oxidative Stress

Exercise as a Protective Tool Against Oxidative Stress

PHYSIOLOGICAL REGULATION OF GENE ACTIVITY BY OXYGEN(O2)

HIF: transcriptional regulator of hypoxic responses

Oxygen-dependent regulation of HIF

Reactive Oxygen Species (ROS) and cellular responses

Oxygen and disease progression

BIOTRANSFORMATION OF XENOBIOTICS AND HORMONES

Absorption of Xenobiotics

Detoxication and Bioactivation

Excretion of Metabolites

BIOMONITORING OF ENVIRONMENTAL POLLUTION

Introduction and Background

Biomarker Molecules

Models Used in Biomonitoring

Biomonitoring of the Quality of Air

Soil Pollution

Pollution and Biomonitoring of Water Resources

Biomonitoring of Textile Safety

Human and Animal Diseases in the Biomonitoring of Environmental Pollution

Attempts at Pollutant Bioidentification

Chemical Analysis of Pollutants and Biomonitoring

INDUSTRIAL USE OF ENZYMES

Historical Background

Enzyme Classification

Enzyme Production

Protein Engineering

Enzyme Technology

Large-Scale Enzyme Applications

Specialty Enzymes

Enzymes in Fine Chemical Production

Future Trends in Industrial Enzymology

NUTRITION AND DIGESTION

Nutrition

Digestion

AUTOTROPHIC, HETEROTROPHIC AND OTHER NUTRITIONAL PATTERNS

Introduction: Different Life Forms

Origin of Life and Energy Sources

Early Chemotrophic Life

Early Phototrophic Autotrophism

First Steps towards Karyotes: From Heterotrophism to Nucleus and Mitosis

From Endosymbiosis to Chloroplasts and Mitochondria

Towards Multicellularism and Task Divisions within Organisms

Organisms in Ecosystems?Symbiosis

NUTRITIONAL NEEDS

Nutritional Needs and Dietary Recommendations

Nutritional Needs

Non-Nutrient Dietary Substances

ALIMENTARY SYSTEMS IN SOME HOMEOTHERMIC VERTEBRATES

General Structure of the Digestive Tract

Carnivores

Herbivores

Birds

INTESTINAL MICROFLORA

Introduction - Composition of the Intestinal Flora

Microbial Ecology of the Intestinal Flora

Effects of the Intestinal Flora

Bacterial Enzymes

Methods to Studying the Intestinal Flora

Intestinal Flora and Immune Defense

Future Aspects

FATTY ACIDS IN HUMAN METABOLISM

Physico-Chemical Properties of Fatty Acids

Biosynthesis of Fatty Acids

Classification and Biological Function of Fatty Acids

Fatty Acids as Constitutional Components of Lipids

Physiological Roles of Fatty Acids

Milk Lipids and Developing Brain

Pathophysiology of Fatty Acids

Therapeutic Use of Polyunsaturated Fatty Acids

VEGETARIANISM AND VEGAN DIET

Food Safety and Various Eating Patterns

Plant-Based Dietary Patterns and Physiological Health Promotion

Plant-Only Diets and Health Risk Control

Dietary Guidelines for Vegetarians

Divergence in Values About Eating

STEROLS, ESPECIALLY CHOLESTEROL AND PHYTOSTEROLS, IN HUMAN METABOLISM

Nutrition and Digestion of Sterols

Sterols in the Human Body

Clinical and Pathobiochemical Significance of Sterols

Sterol Analysis

LOCOMOTION IN SEDENTARY SOCIETIES

Physiological Responses to Exercise

Physical Activity and Health

Ergonomy in the Information Society

Nutrition and Musculoskeletal System

Negative Effects of Training

Doping

MUSCLE ENERGY METABOLISM

Introduction and General Considerations

Phosphate Bond Energy

Anaerobic Energy Metabolism

Mitochondria and Aerobic Metabolism

Metabolism of Glucose and Glycogen in Muscle Fibers

Fatty Acids and Triglycerides as an Energy Source

Skeletal Muscle Fiber Type and Aerobic and Glycolytic Capacity

Muscular Fatigue and Mitochondrial Respiration

Aerobic and Anaerobic Thresholds

Metabolic Profiles of Cardiac Muscle in Action

Metabolism in Smooth Muscle

EXCITATION-CONTRACTION COUPLING IN SKELETAL MUSCLE

Introduction

Voltage sensor of ECC

Calcium release channel of the SR

Control of sarcoplasmic calcium release

Altered ECC in disease

SENSORY-MOTOR POSTURE CONTROL IN LUMBAR DISORDERS

Motor Control

Postural Control

Motor Control of the Lumbar Spine

Lumbar Disorders

Pain and Motor Control

Future Perspectives

PHYSIOLOGICAL BASIS OF EXERCISE

Skeletal Muscle

Cardiovascular Adaptation due to Exercise

Respiratory Regulation During Exercise

Fatigue

LUMBAR MUSCLE FUNCTION AND DYSFUNCTION IN LOW BACK PAIN

Anatomy and Function of the Trunk Extensor and Flexor Muscles

Epidemiological Aspects of LBP

Structural and Pathophysiological Aspects in LBP

Lumbar Muscle Dysfunction in LBP

GAIT, LIMBS AND LIMPING

Introduction

Bipedal being

Balance

Limping

Overweight and osteoarthritis

Joint pains

Exercise, prevention of limping and maintaining motility

Conclusions

FUNCTIONAL MORPHOLOGICAL AND PHYSIOLOGICAL ASPECTS OF HUMAN LOCOMOTION AND POSTURE

Introduction: the Common Mammalian Heritage

Subsystems of Human Locomotor Apparatus and Mechanical Constraints of their Phylogeny

Mechanisms to Drive the Mechanics

Sensory Input

Muscular Recruitment During Locomotion

Locomotion and Postural Motor Control

Postural Motor Control and Sitting

SEDENTARY LIFE - SOURCE OF MULTIPLE HEALTH PROBLEMS

Physiology and Pathophysiology of Sitting

Dynamism to Sitting

Mental Strain and Sitting

Sitting at Schools

Deterioration of Muscle Fitness and Everyday Life

Osteoporosis

Metabolic Problems in Sedentary Life

NEUROMUSCULAR ACTIVITIES IN EXTREME TEMPERATURES

Thermoregulatory Activity of the Motor System

Muscular Performance in Cold and Hot Conditions

Manual Performance in Cold

Skilled Motor Performance in Extreme Temperatures

NEUROPHYSIOLOGY

Introduction and Overview of the Nervous System

Sensory Functions

Motor Functions

Integrative Functions

STRUCTURAL NEUROBIOLOGY

Neural Plasma Membranes and Membrane Proteins

Neural Lipids

Myelin

Cell Adhesion Molecules

Cytoskeleton

AUTONOMOUS NEURAL REGULATION

Sympathetic and parasympathetic divisions of the autonomic nervous system

Autonomic neurotransmitters

Autonomic nervous functions

Changes in autonomous regulation

Introduction

NEURONS, ACTION POTENTIALS AND SYNAPSES

Resting Membrane Potential

Action Potential

Synapses

Neurotransmitter Actions

Neuromuscular Junctions

Synaptic Receptors

Intracellular Messengers

NEUROTRANSMITTERS AND MODULATORS

Introduction

Acetylcholine

Synthesis and Breakdown of Amine Transmitters

Dopamine

5-Hydroxytryptamine

Histamine

Purine Transmitters

Synthesis, Breakdown and Transport of Amino Acid Transmitters

Glutamate

g -Aminobutyrate (GABA)

Glycine

Peptide Transmitters and Modulators

Nitric Oxide and Carbon Monoxide

PHANTOM PAIN

The possible explanation of mechanisms of phantom pain.

The treatment of the phantom pain.

BIOLOGICAL RHYTHMS

Circadian Rhythms are Endogenous

Entrainment

Rhythms in Plants

Rhythms in Animals

Suprachiasmatic Nucleus (SCN)

Projections from the SCN

Rhythms outside the SCN

Clock Genes

Measurement of the Circadian Rhythms

Melatonin

Human Performance and Circadian Rhythm

Jet Lag

Shift Work

Seasonal Depression

SLEEP

Definition of Sleep

Amount and Timing of Sleep

Sleep Stages and the Structure of Nocturnal Sleep

Regulation of Sleep

Disorders of Sleep

Brain and Sleep

Why We Sleep

REGULATION OF FOOD INTAKE

Sensory Signals and Food Intake

Gastrointestinal Neural Signals and Food Intake

Gastrointestinal Hormones and Food Intake

Nutrient Blood Levels in Regulation

Sympathetic Nervous System and Obesity

Adipose Tissue Feedback in Regulation

Food Intake and Centers in the Brain

Psyche and Nutrition

Regulation of Drinking

Social Eating and Drinking

Culture and Selecting Foods

Physical Activity and Food Intake

Eating and Drinking Disorders

STRESS AND COPING

General adaptation syndrome

Anatomy of stress and physiological mechanisms

Differences in stress response

Stress and diseases

Coping and defense

THE NEUROPHYSIOLOGICAL BASIS OF PLEASURE

Needs for Pleasure

Reward Deficiency Syndrome

Love

PLANT PHYSIOLOGY AND ENVIRONMENT : AN INTRODUCTION

Basic Physiology of Plants

Environmental Factors Affecting Plant Physiology

Molecular Genetic Approaches to Study and Affect Plant Physiology

WATER RELATIONS IN PLANTS

Importance of Water to All Living Beings

Water Potential: What Does it Contain?

Absorption of Soil Water by Plant Roots (and Other Parts)

What Else is There in Soil Moisture?

Soil Conditions Affect Plants Greatly

Root Nodules and Mycorrhizae Affect Nutrient and Water Uptake by Roots

Root Pressure and Guttation

Structure of the Water-Conducting Systems in Plants: Xylem and Phloem Sap

Water Transport Inside the Plant

Stomatal Regulation of Water Evaporation

Adaptation to Drought

Transport of Water and Organic Compounds in the Phloem

THE FUNCTIONS OF CHLOROPHYLLS IN PHOTOSYNTHESIS

Structures, Properties, and Natural Occurrence of Chlorophylls

Chlorophylls as Redox Pigments in Photosynthetic Reaction Centers

Functions of Chlorophylls in the Light-Harvesting Antenna Systems

Opportunities Offered by Chlorophyll and Photosynthesis Research

BIOLOGICAL NITROGEN FIXATION WITH EMPHASIS ON LEGUMES

Nitrogen-Fixing Organisms

Importance of Nitrogen Fixation

The Rhizobium–Legume Symbiosis

Evolution and Ecology

Applications

Future Prospects

ROLES OF PLANT GROWTH REGULATING SUBSTANCES

Indole-3-Acetic Acid

Gibberellins

Abscisic Acid

Cytokinins

Ethylene

BIOCHEMICAL INTERACTIONS AMONG PLANTS: ALLELOPATHY AS ECOSYSTEM REGULATOR

Allelopathic Interactions in Plant Communities of Natural Ecosystems

Allelopathy in Aquatic Ecosystem

Allelopathic Interactions in Agroecosystems

Allelopathy in Sustainable Agriculture

Allelopathy in Relation to Environmental Complexity

Future Allelopathic Research

PHENOLOGY OF TREES AND OTHER PLANTS IN BOREAL ZONE UNDER CLIMATIC WARMING

Climatic Adaptation of Plants in Boreal Zone

Trees and Shrubs

Herbs and Grasses

ENVIRONMENTAL POLLUTION AND FUNCTION OF PLANT LEAVES

Ozone as Environmental Pollutant

Plant Responses to Ozone

Combined Action of Air Pollutants and Other Environmental and Climatic Factors in Plants

PLANT-INSECT INTERACTIONS AND POLLUTION

Ecosystem and Host Plant Level Disturbances in Polluted Areas

Responses of Various Plant Feeder Groups to Environmental Changes

Effects of the Most Important Air Pollutants on Plant-Feeding Insects

Effects of Elevated CO2 on Plant-Feeding Insects

Consequences of Rising Temperature for Insect-Plant Interactions

Effects of Enhanced UV-B Radiation on Plant-Feeding Insects

Plant Pathogens and Nematodes in Relation to Air Pollution

Relative Importance of Pollutants and Global Change Factors on Herbivorous Insect Populations

EXTREMOPHILES-BASIC CONCEPTS

Effects of Extreme Conditions on Cellular Components

THERMOPHILY

Habitats and Ecology

Thermophile Diversity and Population Structure

Archaea

Distribution and Speciation of Thermophiles

HYPERTHERMOPHILIC MICROORGANISMS

Biotopes of Hyperthermophiles

Phylogeny of Hyperthermophiles

Taxonomy of Hyperthermophiles

Sampling and Isolation of Hyperthermophiles

Strategies of Life and Environmental Adaptations of Hyperthermophiles

Distribution of Species and Complexity in Hyperthermophilic Ecosystems

Basis of Heat Stability and the Upper Temperature Limit for Life

STRATEGIES OF HYPERTHERMOPHILES IN NUCLEIC ACIDS ADAPTATION TO HIGH TEMPERATURE

The General Problem of Nucleic Acid Stability at High Temperature

Thermoprotection of RNA in Hyperthermophiles

Thermoprotection of DNA in Hyperthermophiles

THERMOSTABILITY AND THERMOACTIVITY OF EXTREMOZYMES

Enzyme Stability

The Structural Basis of Thermostability

Observations from Nature

Lessons From Directed Evolution

Intrinsic versus Extrinsic Factors in Enzyme Thermostability

Thermoactivity

UNIQUE ASPECTS OF THE HYPERTHERMOPHILE PROTEOME

Systematics of the Order Thermococcales

Characterized Enzymes and Proteins

Starch Catabolism

Functional and Structural Genomics

COMPATIBLE SOLUTES IN MICROORGANISMS THAT GROW AT HIGH TEMPERATURE

Strategies for Osmotic Adaptation in Microorganisms

Compatible Solutes of Organisms that Live at High Temperatures

The Distribution of Compatible Solutes Within the Tree of Life

Reflections on the Physiological Role of Compatible Solutes in Thermoadaptation

The Effect of Hypersolutes on Protein Stability

Pathways for the Synthesis of Compatible Solutes in Thermophiles and Hyperthermophiles

HEAT-SHOCK RESPONSE IN THERMOPHILIC MICROORGANISMS

Even Extreme Thermophiles Display Heat-Shock Response

Archaeal Chaperonins

Archaeal Chaperonins Are Biotechnological Tools

Perspectives

THERMOACTIVE ENZYMES IN BIOTECHNOLOGICAL APPLICATIONS

Extreme Environments as a Source of Novel Thermoactive Enzymes

Cultivation of Extremophilic Microorganisms

Screening Strategies for Thermoactive Enzymes

Starch-Processing Enzymes

Cellulases

Thermoactive Xylanases

Pectin-Degrading Enzymes

Chitinases

Proteolytic Enzymes

Glucose Isomerases, Alcohol Dehydrogenases, and Esterases

Polymerase Chain Reaction (PCR)

PSYCHROPHILY AND RESISTANCE TO LOW TEMPERATURE

Cold-Adapted Microorganisms

Cold-Adaptation Mechanisms

Cold Shock and Cold Acclimation

Cold Resistance and Cold Sensitivity

ICE ECOSYSTEMS AND BIODIVERSITY

Known and unknown ice ecosystems

Open questions

MEMBRANE ADAPTATION AND SOLUTE UPTAKE SYSTEMS

Membrane Structure and Lipid Organization

Structure of Transport Proteins

Lipid Adaptation to the Cold

Transport of Small Molecules

Effects of Lipid Composition on Transport

Solute Uptake and Ecology in the Cold

CATALYSIS AND LOW TEMPERATURE: MOLECULAR ADAPTATIONS

The Psychrophilic Context

Kinetic Optimization of Cold-Active Enzymes

Stability of Psychrophilic Enzymes

Activity-Flexibility-Stability Relationships

COLD-SHOCK RESPONSE IN MICROORGANISMS

Membranes

Transport Systems

Metabolic Processes

Antifreeze Compounds and Intracellular Effectors

Nucleic Acids and Nucleic Acid-Binding Proteins

Protein Synthesis

Cold-Sensing Mechanisms

Cold Shock and Other Stress Responses

HETEROLOGOUS GENE EXPRESSION IN COLD-ADAPTED MICRO-ORGANISMS

Heterologous Protein Production in Bacteria other than Escherichia coli

Cold-Adapted Bacteria Transformation

Construction of Cold Genetic Systems and their Cold Host Profile

The a -Amylase Example of Heterologous Protein Production in Cold-Adapted Bacteria

COLD-ACTIVE ENZYMES AS NEW TOOLS IN BIOTECHNOLOGY

Advantages of Cold-Active Enzymes in Biotechnology

Improvement of Enzyme Yield and Thermostability

Biotechnological Potential of Cold-Active Enzymes

FREEZE TOLERANCE

Strategies for Survival at Subzero Temperatures

Freeze Tolerance

FREEZING AVOIDANCE IN POLAR FISHES

Diversity of Fish Antifreeze Proteins

Antifreeze Property and Function

Evolutionary Origins and Pathways of Antifreeze Proteins

Environmental Driving Force for Antifreeze Evolution

GLOBAL PERSPECTIVES IN HEALTH

Definition and Concepts

Critical Questions in Health

The Measurement of Health

Health in a Global Context

A Synopsis of Health Issues

EPIDEMIOLOGY: HEALTH AND DISEASE IN POPULATIONS

What Is Epidemiology?

Purposes of Epidemiology

Defining and Measuring Health and Disease

Descriptive Epidemiology

Epidemiological Approaches to Understanding Causal Relations

Experimental Epidemiology: The Randomized Trial

Epidemiology for Health Systems: Use in Policy, Planning, and Assessment

The Future of Epidemiology

HEALTH INFORMATION SYSTEMS

What is a Health Information System?

Health Information Systems and Health Development

The Structure of Health Information Systems

Towards Action-Led Health Information Systems

Educational Requirements

HEALTH-RELATED INDICATORS

A Reference Framework to Health-Related Indicators

From Conceptual Framework to Indicators -- Health State Expectancies

EPIDEMIOLOGY AND SURVEILLANCE

Evolution of Surveillance

Definition, Purpose, and Objective of Surveillance

Elements of Surveillance

Organization and Functions of Surveillance Systems

Surveillance and Research

Emerging Disease Threats and International Surveillance

FAMILY HEALTH

Family, Families

Family as a Life-Support System

Family as a Health-Support System

Family Health, Family Care

MENTAL HEALTH

The Social and Economic Cost of Mental Illness

Classification and Diagnosis of Mental Disorders

The Symptoms and Sequelae of Mental Illness

Epidemiology of Mental Disorders

The Multifactorial Causation of Mental Disorders

Common Psychosocial Risk Factors

Treatment and Prevention of Mental Disorders

PREVENTION AND CONTROL OF COMMUNICABLE DISEASES

Infectious Diseases Causing High Mortality

Infectious Diseases Causing Disability

Emerging and Reemerging Infections

Causes of the Renewed Spread of Infectious Diseases

Limiting the Spread and Consequences of Infectious Diseases

PREVENTION AND CONTROL OF NONCOMMUNICABLE DISEASES

Chronic Noncommunicable Diseases and World Health

Economic and Social Implications of the Emerging Epidemics of Noncommunicable Diseases

General Principles and Main Components of the Control of Noncommunicable Diseases

HEALTH CARE SYSTEMS

Health Policies and Systems

Primary Health Care

Family Health

Economics of Health Care

Health Information Systems

Long-Term and Domiciliary Care

Palliative and Terminal Care

Quality Assurance in Health Care

Diagnostic, Therapeutic, and Rehabilitation Technology

Genetics and Tissue Engineering

PRIMARY HEALTH CARE: THE KEY TO HEALTH FOR ALL

Background: Emergence of a Right to Health

Experience: Emergence of a Set of Principles

Authorship and Choice of a Name

A Short, Formal Definition of PHC

Attributes and Content of PHC

Community Determination of Basic Needs Related to Health

Determination of Health Targets for HFA/PHC

Practical Implementation of PHC

Who Pays for What, and Who Benefits?

Health for All and PHC after the Year 2000

QUALITY ASSURANCE

Terminology

Background

Quality Assurance in Developing Countries

Scope of Quality Assurance

Health Care Quality Parameters

Standards

Consumer Movements

Patient Satisfaction as an Indicator of Quality

Approaches to Quality Assurance

Utilization of Health Services

Research on Quality Assurance

Information

Organized Quality Assurance Systems: Managed Care

Contention

Competition

PREVENTIVE, THERAPEUTIC AND DIAGNOSTIC TECHNOLOGIES. DEVELOPMENT AND PERSPECTIVES

Preventive Medicine

Therapeutics

Surgical Cure

Diagnostic Technologies

Perspectives

HEALTH TECHNOLOGY ASSESSMENT: SUSTAINING EQUITY IN HEALTH CARE

The Development of Health Technology Assessment

Establishing Effectiveness Evidence

The Appropriate Role for Health Technology Assessment

Current Developments: Strategic HTA

HTA in Decision-making: An illustrated model

Looking Ahead

HEALTH TELEMATICS AND ITS SOCIETAL IMPLICATIONS

Background

Health Telematics Applications

Societal Implications of Health Telematics

DOMICILIARY, PALLIATIVE, AND TERMINAL CARE

Palliative Care . . . When to Begin?

Symptom Control

Spiritual Suffering

Ethical Issues

ETHICAL ISSUES IN HEALTH

The Rise of Bioethics

The Role of (Bio)Ethics

Ethical orientations

Duty-based (or deontological) ethics

Consequentialist or utilitarian ethics

Other Bioethical Orientations

Feminist Ethics

(Bio)Ethical Principles

Respect for Persons

Beneficence

Non-Maleficence

Justice

Levels of Ethical Analysis

Reproductive and Sexual Health Ethics

Research Ethics

Ethics and the Law

Ethics and Human Rights

BIOETHICS AND BIOTECHNOLOGY

Biotechnology will Play a Bigger Role in our Lives

Agricultural Biotechnology

The Human Genome Project

Cloning

Xenotransplantation

Human Embryonic Stem Cells

Developing Countries, Bioethics and Biotechnology

A Vision for the Future

CODES OF CONDUCT AND ETHICAL GUIDELINES

Codification and Professionalism

Codes, Guidelines and Pre-Existing Practice

Medical and Related Codes of Conduct

The Scope of Codes and Guidelines

Law and Legal Enforcement

Ethical Interpretation and Application

INFORMED CONSENT IN CLINICAL PRACTICE AND BIOMEDICAL RESEARCH

History

Essential Information for Patients and Research Subjects

Exceptions to Consent

Patient Competence to Consent

Informed Consent in the Clinical Setting

Informed Consent in Biomedical Research involving Human Subjects

Obtaining Informed Consent of Subjects

Research Involving Children and Other Incompetent Subjects

Consent to Epidemiological and Other Studies with Community Involvement

Consent in Externally Sponsored Research

Factors Which Nullify Informed Consent

Future of Informed Consent

HEALTH ETHICS, EQUITY AND HUMAN DIGNITY

Definitions and Concept

Ethics and Major Determinants of Health

Future Oriented Approach

NEW PROBLEMS IN GLOBAL HEALTH

The World Order

New Microbial Threats, the Environment in Which They Develop, and Related Matters

Food Chain Alterations

Environmental toxins

Industrial Chemicals and Accidents; Occupational Hazards; Trauma

Human Gene Pool Changes

Armed Conflict and Violence

Family Systems and Values

Lifestyle

New Methods of Spread of Disease

Politicization

Human Rights

Poverty

Monopolies

Macroeconomic Policy, Globalization, International Labor Regulation, International Patents, Etc.

Genetically Modified Foods

GLOBAL AGING

The Elderly

Aging Societies

Implications for Health

The Adaptation of Society

URBAN GROWTH AND HEALTH

Urban Development

Health Implications of Urban Growth

Future Challenges

IMPLICATIONS OF ATMOSPHERIC AND CLIMATIC CHANGE FOR HUMAN HEALTH

The Context of Atmospheric and Climate Change

Stratospheric Ozone Depletion

Biological and Human Health Impact of Increased Ultraviolet Radiation Flux

Greenhouse Gases and Global Climate Change

Effects of Climate Change on Health

Public Health Action

HEALTH IN BORDER AREAS

Definitions

Current and Continuing Concerns of Health and Development in Border Areas

International Recognition of Health in Border Areas

Potential Promotion and Development

DISASTERS AND CONFLICTS

Disaster Medicine

Disaster Epidemiology

Action against Disasters

Emergency Medical Supplies

Disaster Terminology

Conflicts

Humanitarian Medicine

VACCINATION IN DEVELOPING COUNTRIES: PROBLEMS, CHALLENGES AND OPPORTUNITIES

Challenges to Improving Vaccination

Obstacles to Effective Vaccination

Solutions to Problems of Access and Coverage

Mechanisms: Cooperation Between Industrialized Nations and Developing Nations

Recent Initiatives—A Brighter Future?

Role of the World Health Organization

The Future

WATER AND HEALTH

Water-Related Diseases

Public Health Impact of Water-Related Diseases

Control of Water-Related Diseases

Water Treatment Processes

Water Quality Control

Utilization of Water and Related Resources

Future Priorities

WATER AND HEALTH

CLASSIFICATION OF WATER-RELATED DISEASE

Definitions and systems for classifying water related disease

Water-related infection

Non-infectious disease related to water

Implications for water related surveillance

Water Associated Disease

BURDEN OF DISEASE: CURRENT SITUATION AND TRENDS

Water-related health outcomes

Trends in risk factors

Trends in health outcomes

Burden of disease

Regional Patterns

Discussion

TRANSMISSION AND PREVENTION OF WATER-RELATED DISEASES

Water-borne Diseases

Water-washed Diseases

Water-based Diseases

Water-related Insect Vector Diseases

GOALS OF WATER TREATMENT AND DISINFECTION: REDUCTION IN MORBIDITY AND MORTALITY

Piped water networks and waterborne disease

The diseases

Water treatment: control of pathogens

DISEASES ASSOCIATED WITH DRINKING WATER SUPPLIES THAT MEET TREATMENT AND INDICATOR SPECIFICATIONS

Indicators of water quality and public health

Public health surveillance of waterborne disease

Epidemiologic studies of endemic waterborne disease

Etiology and causes of endemic water-attributable disease

Quantitative microbial risk assessment

Costs of undetected waterborne diseases

NEW AND EMERGING WATERBORNE INFECTIOUS DISEASES

Infectious diseases

New, emerging, re-emerging and resurgent infectious diseases

Waterborne infectious diseases

Viral agents

Bacterial agents

Protozoal agents

SAFE DRINKING WATER IN THE TWENTY FIRST CENTURY: PRIORITIES FOR PUBLIC HEALTH

Risk Assessment

The Pathogens

The Phenomenon of "New Disease"

Biofilms

Chemicals

Gene Arrays

Priorities in Public Health - Conclusion

DRINKING WATER SUPPLIES

MONITORING DRINKING WATER SUPPLIES

Introduction

Scientific Basis

Principles and Approaches

Legislative and Regulatory Aspects and Implementation

Conclusions

ZOONOSES ACQUIRED THROUGH DRINKING WATER

General issues of zoonotic disease acquired through drinking water

Zoonotic Protozoa

Zoonotic bacteria

Zoonotic Helminths

Potential waterborne zoonoses

MICROBIOLOGICAL WATER QUALITY ASSESSMENT (CATCHMENT TO TAP)

Introduction

Microbiological Water Quality Indicators

Methods of Assessment

Water Quality Management

Future Trends and Perspectives

EPIDEMIOLOGIC STUDIES OF DISINFECTANTS AND DISINFECTANT BY-PRODUCTS

Epidemiologic Study Designs

Uncertainty of Risk Estimates

Cancer Risks

Adverse Reproductive and Developmental Outcomes

Cardiovascular Risks

Other Adverse Health Effects

Evaluating the Causality of Reported Associations

Discussion

HEALTH EFFECTS OF CHEMICAL CONTAMINATION OF DRINKING WATER SUPPLIES

Introduction

Naturally occurring chemical contaminants

Contaminants arising from agriculture

Contaminants from industry and human habitation

Contaminants introduced in drinking water treatment

Materials used in contact with drinking water

Water Safety Plans

New sources of drinking water

Conclusions

UNCONVENTIONAL SOURCES OF WATER SUPPLY

Water Reclamation

Desalination of Seawater

POINT-OF-USE WATER TREATMENT FOR HOME AND TRAVEL

Potential Solutions for Small Communities

Point-of-Use and Personal Water Treatment

Water Treatment Technologies for Home Applications

Introduction

Conclusions

BOTTLED DRINKING WATER

Regulatory framework

History

Impact

Trends in the Bottled Water Market

Marketing Strategies and Public Perception

The Politics of bottled water

TREATMENT AND SAFE STORAGE OF WATER IN HOUSEHOLDS WITHOUT PIPED SUPPLIES OF TREATED WATER

Introduction

Boiling

Chlorination

Solar Disinfection

Ceramic Filtration

Biosand (Intermittent Sand) Filters

Flocculation-Disinfection

Safe Storage

Cost and affordability

Acceptability, Affordability and Sustainability

WATER RESOURCES

QUANTIFYING HEALTH RISKS IN WASTEWATER IRRIGATION

Introduction

Quantitative Microbial Risk Analysis

Post-treatment Health-protection Control Measures

Helminth Eggs

Wastewater Treatment

IMPACTS OF EUTROPHICATION ON THE SAFETY OF DRINKING- AND RECREATIONAL WATER

What is eutrophication?

Effects of eutrophication

Cyanobacteria

Health implications of eutrophication from consumption and recreational exposure

Guideline values, policy and legislation

The Future

Conclusion

Introduction

GROUNDWATER AND PUBLIC HEALTH

Subsurface Behavior of Viruses

Factors Affecting Attachment of Viruses to Soil

Factors Affecting Virus Inactivation in the Subsurface

Advection and Dispersion of Viruses

Model Viruses

Virus Removal by Soil Passage

Removal of Bacteria and Protozoa by Soil Passage

Recommendations and Future Developments

AQUACULTURE AND MARICULTURE

Introductory statement

Nature of the industry

Sources of fecal contamination impacting water quality

Pathogens contaminating molluscan shellfish and growing waters

Toxins and chemicals

Control strategies for bivalve molluscs

Future prospects

RECREATION IN NATURAL WATER RESOURCES

Introduction

Recreational Waters

Risks while Recreating

Guidelines and Standards for Monitoring

Pollution

Sources of Fecal Pollution

Reservoirs of Fecal Pollution and Toxins

Impacts and Events

Protection of Recreational Water Sites

Recreating Safely

DRY SANITATION TECHNOLOGIES - CAN THEY BE SUSTAINABLE?

Introduction

Challenges posed in the up-scaling of onsite dry sanitation systems

What happens in the pit?

Implications of research findings on long term sustainability of VIPs

A concerning social phenomenon related to dry sanitation

Conclusions

CONSTRAINTS TO IMPROVING WATER AND SANITATION SERVICES

Current status of water supply and sanitation coverage in the world

Main constraints and their consequences

Towards the 21st Century

WATER RECLAMATION AND REUSE

Introduction

Water Reuse Terminology and Definitions

Evolution of Water Reclamation and Reuse

Water Reuse - Current Status in the United States

Water Reuse in Other Parts of the World

Spectrum of Reclaimed Water Quality and Treatment Technology

Reclaimed Water Applications

Water Quality Criteria and Regulatory Requirements

Infrastructure for Water Reuse

Observations and Future Trends in Water Reuse

ROLE OF WATER REUSE IN MANAGEMENT OF URBAN WATER RESOURCES

Introduction

Uses for recycled water in the Urban Environment

Production of Recycled water

The Market

The pricing structure

An appropriate regulatory environment

User and community acceptance

Conclusion

THE USES OF RECYCLED WATER

Introduction

Reuse for Agriculture

Amenity Uses

Domestic Non Human Consumption Urban Use

Indirect Potable (Drinking Water) Use

Industrial Use

Environmental Use

The viability of recycled water use - Economics

Components of Successful Water Recycling

COMING TO TERMS WITH NATURE: WATER REUSE NEW PARADIGM TOWARDS INTEGRATED WATER RESOURCES MANAGEMENT

Towards an integral definition of water reuse

How to overcome people’s fear of reused water

What we know about natural water reuse

Natural water reuse origin

Situation by type of water body

Control

HELMINTH OVA CONTROL IN WASTEWATER AND SLUDGE FOR AGRICULTURAL REUSE

General Information

Helminth Ova in Wastewater and Sludge

Helminth Ova Characteristics

Helminth Ova Removal from Wastewater

Helminth Ova Inactivation in Sludge

Helminth Ova Inactivation in Faecal Sludge

Analytical Techniques

PHARMACOLOGY

BIOLOGICAL SCIENCE FOUNDATIONS

The Beginning of Modern Biological Science

Genetics and Evolution

The Molecular Basis of Life

The Molecular Tree of Life

The Limits of Life on Earth

Life Elsewhere in the Universe

GENETICS AND MOLECULAR BIOLOGY

Signal Transduction via Plasma Membrane to Gene Expression

Signal Transduction of Light in Animals (Vertebrates), Neurospora Crassa, and Plants

Epigenetic Regulation of Gene Expression in Eukaryotes

HISTORY AND SCOPE OF GENETICS; EPIGENETIC REGULATION OF GENE EXPRESSION

RNA interference

Repeat induced point mutation (RIP)

Genetic regulation by Polycomb group (PcG) proteins

Epigenetics in Arabidopsis thaliana

Paramutation

MENDELIAN GENETICS AND ITS DEVELOPMENT

The Classical Theory of Direct Inheritance

Mendelian Genetics

Molecular Genetics

Population Genetics

CLASSICAL TO MODERN GENETICS

Bacillus subtilis

Agrobacterium tumefaciens

Neurospora crassa

Aspergillus nidulans

Lotus corniculatus L. var. japonicus Regel

BACTERIAL AND YEAST GENETICS - A HISTORICAL ACCOUNT

Bacterial genetics

Yeast genetics

DIPLOID AND HAPLOID GENGETICS AND RECOMBINATION MECHANISMS

General Recombination

Recombination and Pairing of Homologous Chromosomes

Induction of Recombination

Establishment of Recombination

Structure and Function of the Synaptonema Complex (SC):

Transcription and Recombination

Somatic recombination/ Diploid Genetics

Genes and Proteins in Meiotic Cells / Haploid Cell Genetics

Meiosis and Environment

NON-MENDELIAN INHERITANCE

Chloroplast Inheritance

Mitochondrial Inheritance

GENOME ANALYSIS OF CYANOBACTERIA

Sequence Features of the Synechocystis sp. PCC6803 Genome

Assignment of RNA and Protein-Coding Genes in the Synechocystis Genome

Characteristic Features of Synechocystis Genes

Functional Genomics in Synechocystis

Databases Supporting Synechocystis Research

Genome Analysis of Other Cyanobacteria

GENOME SCIENCE OF CYANOBACTERIA, GREEN ALGAE AND PLANTS (GENOME SCIENCE OF GREEN ALGAE)

Chlamydomonas as a model organism for plants

Nuclear genome

Chloroplast genome

Mitochondrial genome

GENOMIC ANALYSIS OF ARABIDOPSIS THALIANA

Introduction: Why is Arabidopsis a Model Plant Species?

Small Size and Simple Organization of the Arabidopsis Genome

Chromosomes and Maps

Analysis of the Complete Genome Sequence

Chromosomal Elements: Centromeres, Telomeres, and rDNA Repeats

Arabidopsis Plastid and Mitochrondrial Genomes

Functional Genomics of Arabidopsis

Perspectives

GENOME SCIENCE OF INVERTEBRATES: THE NEMATODE C.ELEGANS

What is a nematode?

What is C.elegans ?

Genetic resources of C.elegans: CGC

Genomic resources

Resources for gene expression and function

GENOME SCIENCE OF THE RAT

Genome Resources

Genetic Engineering

Positional Cloning of Monogenic Traits

QTL Analysis

GENOME SCIENCE OF VERTEBRATE

The Importance of the Mouse Genome and Transcriptome Study

The History of Mouse Genetics

The Determination of Mouse Genome Sequences

A Full-Length Mouse cDNA Project

Positional Cloning

cDNA Encyclopedia and the Positional Candidate Approach

Functional Genomics

ETHNOPHARMACOLOGY: AN OVERVIEW

Methods

Contexts of Medicinal Plant Use

Multicontextual Plant Use

INTEGRATING ETHNOGRAPHIC AND ECOLOGICAL PERSPECTIVES FOR ETHNOPHARMACOLOGY FIELD RESEARCH

Anthropological (Ethnographic) Field Methods

Integrating Ethnographic and Ecological Field Methods

MANAGING ETHNOPHARMACOLOGICAL DATA: HERBARIA, RELATIONAL DATABASES, LITERATURE

Historical trends

Present trends

TRADITIONAL MEDICINAL PLANTS FOR THE TREATMENT AND PREVENTION OF HUMAN PARASITIC DISEASES

Protozoa

Helminths

THE FUTURE OF ETHNOPHARMACOLOGY: SEEKING A TRANSDISCIPLINARY AND CULTURALLY GERMANE SCIENCE

Introduction – Defining Ethnopharmacology

Objectives of Ethnopharmacology Research

Future Trends

FUNDAMENTALS OF BIOLOGICAL SCIENCE: AN EVOLUTIONARY APPROACH

REPRODUCTIVE AND DEVELOPMENTAL BIOLOGY

PHYSICAL ANTHROPOLOGY

DEVELOPMENT AND ECONOMIC ANTHROPOLOGY: THE CONTRIBUTIONS OF ECONOMIC ANTHROPOLOGY TO INTERNATIONAL DEVELOPMENT PRACTICE

Introduction

Economic Anthropology

International Development

Contributions of Economic Anthropology to International Development Practice

Conclusion

Notes

PHYSIOLOGICAL ANTHROPOLOGY: EFFECTS OF ARTIFICIAL LIGHT ENVIRONMENT ON HUMANS

Light and human